Bioisosteres in drug discovery: focus on tetrazole

Astellas' Drug Discovery Strategy: Focus on Oncology

Based on the goal of delivering innovative and reliable pharmaceutical products to cancer patients for whom no effective treatments exist, Astellas is focusing its efforts on a strategy of precision medicine in its drug discovery which is carried out at three research sites with diversity in their research platforms and research styles.

Application of Bioisosteres in Drug Design

Computational methods for drug design and discovery: focus on China.

In the past decades, China's computational drug design and discovery research has experienced fast development through various novel methodologies. Application of these methods spans a wide range, from drug target identification to hit discovery and lead optimization. In this review, we firstly provide an overview of China's status in this field and briefly analyze the possible reasons for this...

A chemogenomic approach to drug discovery: focus on cardiovascular diseases.

References to individual protein targets and bioactive small molecules associated with cardiovascular diseases can be found in multiple bibliographic sources. From mining these sources, a highly curated list of 214 cardiovascular targets was collected and organised using functional classification schemes for the main protein families of therapeutic relevance, namely, enzymes, G-protein-coupled ...

Ethnobotany, Ethnopharmacology and Drug Discovery

     This manuscript is a review of a number of ethnobotany and ethnopharmacology texts and papers in order to arrive at current understanding and scope of ethnobotany and ethnopharmacology. It includes either a brief definition of both fields and presenting some examples on them. Also it has a glimpse on the geographical coverage of research works throughout the world, important issue of prope...